Senior Manager, Clinical Data Management

Paradigm is rebuilding the clinical research ecosystem by enabling equitable access to trials for all patients. Our platform enhances trial efficiency and reduces the barriers to participation for healthcare providers. Incubated by ARCH Venture Partners and backed by leading healthcare and life sciences investors, Paradigm’s seamless infrastructure implemented at healthcare provider organizations, will bring potentially life-saving therapies to patients faster. Our team hails from a broad range of disciplines and is committed to the company’s mission to create equitable access to clinical trials for any patient, anywhere. Join us, and bring your expertise, passion, creativity, and drive as we work together to realize this mission. The Senior Manager of Clinical Data Management (CDM) is a senior leader within Paradigm’s data organization, responsible for overseeing the execution, quality, and operational excellence of data management activities across Phase IV, post-marketing, and real-world evidence (RWE) studies. Reporting to the Head of Clinical Data Management, this leader plays a key role in shaping data delivery strategy, driving cross-functional collaboration, and ensuring consistent, high-quality outcomes across a growing portfolio. This position requires strong technical expertise, exceptional leadership capability, and the ability to operate strategically while maintaining hands-on oversight of complex data workflows. What You'll Do: Leadership & Team Development: • Lead, mentor, and develop a high-performing team of Clinical Data Managers and CDM operations staff. • Oversee workload allocation, staffing plans, competency development, and performance management. • Foster a culture of excellence, continuous improvement, and accountability within the CDM function. Portfolio Oversight & Data Delivery Excellence: • Provide senior oversight of end-to-end CDM activities across multiple studies, including database development, CRF design, edit check specification, cleaning and reconciliation workflows, and database lock. • Ensure predictable delivery of data management milestones through proactive oversight of timelines, metrics, and quality indicators. • Anticipate operational risks and lead resolution efforts in collaboration with cross-functional partners. Cross-Functional Partnership: • Collaborate closely with Clinical Operations, Biostatistics, Safety, Regulatory, Quality, Product, and Engineering to ensure integrated and efficient data delivery. • Serve as a senior CDM representative in cross-functional study meetings, troubleshooting sessions, and strategic planning discussions. • Align CDM workflows with broader study goals and portfolio-level priorities. Process Improvement & Operational Innovation: • Lead the development, refinement, and adoption of CDM SOPs, templates, libraries, and operational playbooks. • Drive initiatives to streamline workflows, strengthen data quality controls, and enhance scalability across the CDM organization. • Support digital transformation initiatives, including automation, modern EDC capabilities, and advanced data review tools. Sponsor Engagement & Delivery Management: • Serve as a senior CDM point of contact for sponsors, ensuring transparent communication, timely delivery, and trusted partnership. • Provide proactive updates, risk assessments, and strategic recommendations to internal and sponsor stakeholders. • Contribute to proposal development, data strategy discussions, and operational feasibility assessments for new and ongoing programs. Who You Are: • 8–12 years of clinical data management experience, with substantial experience leading complex studies or multi-study portfolios. • Proven leadership experience managing data teams and driving high-quality delivery in fast-paced environments. • Deep expertise in EDC systems, CDISC standards, data cleaning and reconciliation processes, and regulatory requirements (ICH-GCP, 21 CFR Part 11, GDPR). • Strong communication skills with the ability to influence, collaborate, and lead across diverse technical and operational teams. • Highly organized, analytical, and committed to data integrity, operational excellence, and continuous improvement. • Able to operate strategically while remaining hands-on with complex problem-solving when needed. The base compensation range is $180,000 – $210,000 USD per year. Actual salaries will vary based on candidates' qualifications, skills, and location. What You’ll Receive: Paradigm Health offers a comprehensive Total Rewards package to support your well-being and success, including: • Competitive health, dental, and vision insurance • Mental health support for you and your family through Spring Health • Equity package • Unlimited paid time off (PTO) • 16 weeks of paid parental leave • Flexible work options – remote and hybrid arrangements • Company-paid life insurance • Company-paid short-term and long-term disability coverage • One Medical membership • 401(k) plan with company match At Paradigm, we are committed to providing equal employment opportunities to all qualified individuals. We encourage and welcome candidates from all backgrounds and perspectives to apply for our open positions. We are interested in all qualified individuals and ensure that all employment decisions are based on job-related factors such as skills, experience, and qualifications. Apply tot his job