[Remote] Bioinformatics Engineer - Nextflow and AWS Specialist (6 months contract)

Note:The job is a remote job and is open to candidates in USA. Twist Bioscience is a company focused on synthesizing genes from scratch, contributing to advancements in various fields including health care and agriculture. They are seeking aSenior Bioinformatics Engineer with expertise in Nextflow and AWS to architect and optimize bioinformatics pipelines for large-scale NGS data processing. Responsibilities • Architect and develop advanced Nextflow pipelines for NGS data processing, analysis, and multi-step workflow orchestration • Deploy, operate, and optimize pipelines on AWS EKS and Batch • Build and maintain Docker-based container environments for reproducible and portable bioinformatics pipelines • Develop and maintain robust Python tooling to support workflow automation, QC reporting, monitoring, and data integration • Implement workflow observability, logging, and bolthires-optimized execution strategies for large-scale genomic data • Collaborate with sequencing, bioinformatics, and platform engineering teams to improve workflow reliability and performance • Establish best practices for pipeline versioning, continuous integration, automated testing, and cloud-based deployment • Ensure pipelines are highly reproducible, fault-tolerant, and suitable for production environments in regulated or high-stakes settings Skills • 5+ years of experience in bioinformatics, computational biology, workflow engineering, or related fields • Expert-level proficiency in Nextflow, including DSL2, modules, workflow optimization, and pipeline debugging • Strong hands-on experience with AWS, particularly: EC2 compute environments, S3 for cloud storage, EKS for workflow execution • Deep expertise with Docker, including custom image creation, multi-stage builds, and best practices for pipeline reproducibility • Strong Python development skills with production-level experience, testing frameworks, packaging, and tooling • Experience operating in cloud-native environments with distributed computing, autoscaling, bolthires-optimization, and workflow orchestration • Solid understanding of NGS data formats, sequencing workflows, and common bioinformatics tools • Strong Linux skills and experience with bolthires/CD systems • Ability to work effectively in PST time zone (remote or onsite) • Experience with Java/Groovy • Experience building and using APIs • Experience with Nextflow Tower or similar workflow management platforms • Experience configuring Kubernetes workloads for genomics pipelines • Background in synthetic biology, DNA design, or high-throughput genomic library analysis • Experience collaborating with wet labs or platform teams on sequencing pipeline requirements Company Overview • Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.It was founded in 2013, and is headquartered in San Francisco, California, USA, with a workforce of 501-1000 employees. Its website is Company H1B Sponsorship • Twist Bioscience has a track record of offering H1B sponsorships, with 13 in 2025, 14 in 2024, 23 in 2023, 19 in 2022, 4 in 2021, 6 in 2020. Please note that this does not guarantee sponsorship for this specific role. Apply tot his job