Senior Scientist, Medicinal Chemistry

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! SENIOR SCIENTIST, MEDICINAL CHEMISTRY SUMMARY: We are seeking a motivated and innovative individual to join our Medicinal Chemistry team as a Senior Scientist. The successful candidate will play a key role in synthesizing ligands or nucleoside monomers, incorporating them into therapeutic oligonucleotides, and performing bioconjugation of oligonucleotides to ligands targeting cell surface receptors. This position offers a unique opportunity to collaborate with cross-functional teams and contribute directly to the research and development of breakthrough therapies that have the potential to transform patients’ lives. REQUIREMENTS: • Ph.D. in Organic or Nucleic Acid Chemistry with at least 2 years of post-doctoral experience in academia or industry • Experience in nucleoside/oligonucleotide synthesis and purification • Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography) • Experience with automated lab equipment (e.g., NMR, LC-MS, etc) • A track record of scientific productivity as evidenced by high quality publications and/or patents • Excellent communication skills and the ability to succeed in a team environment. • An ability to be productive and successful in a fast-paced, interactive, and innovative work environment Please visit our website, for more information about Ionis and to apply for this position; reference requisition #IONIS003828 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: The pay scale for this position is $130,476 to $160,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. Apply tot his job