Senior Medical Science Liaison (Northeast/U.S. Oncology)
Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.
The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.
This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.
Your role
Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)
Scientific Exchange & External Engagement
Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC
Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy
Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC
Clinical Development & Trial Execution Support
Support Tango-sponsored clinical trials, with emphasis on:
Site identification and activation
Enrollment support and investigator engagement
Ongoing scientific dialogue to enhance trial conduct
Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams
Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution
Insight Generation & Strategic Contribution
Capture and synthesize high-quality, hypothesis-driven insights from the field related to:
Trial design and execution
Competitive landscape
Future evidence needs
Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness
Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve
Advisory Boards, Congresses & Scientific Presence
Support planning and execution of advisory boards, investigator meetings, and other scientific forums
Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology
Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution
Cross-Functional Collaboration & Compliance
Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners
Serve as a scientific resource to internal stakeholders
Uphold the highest standards of compliance, scientific integrity, and ethical engagement
What You Bring
Education & Experience
8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
Experience in PDAC, GI malignancies, or NSCLC strongly preferred
Prior experience supporting clinical-stage or pre-launch oncology assets highly valued
Skills & Attributes
Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
Demonstrated strength in insight generation, synthesis, and communication
Comfortable operating in a fast-moving, high-accountability biotech environment
Excellent collaboration skills across matrixed teams
Strong understanding of U.S. clinical research and healthcare environments
Compliance & Technical Requirements
Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
Commitment to compliant, ethical scientific exchange
Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)
Work Environment
Field-based role in the Northeast (Boston/New York), with residence required within assigned territory
~ 50% domestic travel expected, with significant time spent with external scientific partners
Why Join Tango Medical Affairs?
Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
Expand and establish Tango as a credible clinical scientific leader in precision oncology
Work in a lean, collaborative environment where your scientific judgment and execution matter
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
#LI-Remote
Salary range
$157,600—$236,400 USD
Apply To This Job
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.
The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.
This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.
Your role
Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)
Scientific Exchange & External Engagement
Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC
Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy
Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC
Clinical Development & Trial Execution Support
Support Tango-sponsored clinical trials, with emphasis on:
Site identification and activation
Enrollment support and investigator engagement
Ongoing scientific dialogue to enhance trial conduct
Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams
Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution
Insight Generation & Strategic Contribution
Capture and synthesize high-quality, hypothesis-driven insights from the field related to:
Trial design and execution
Competitive landscape
Future evidence needs
Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness
Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve
Advisory Boards, Congresses & Scientific Presence
Support planning and execution of advisory boards, investigator meetings, and other scientific forums
Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology
Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution
Cross-Functional Collaboration & Compliance
Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners
Serve as a scientific resource to internal stakeholders
Uphold the highest standards of compliance, scientific integrity, and ethical engagement
What You Bring
Education & Experience
8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
Experience in PDAC, GI malignancies, or NSCLC strongly preferred
Prior experience supporting clinical-stage or pre-launch oncology assets highly valued
Skills & Attributes
Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
Demonstrated strength in insight generation, synthesis, and communication
Comfortable operating in a fast-moving, high-accountability biotech environment
Excellent collaboration skills across matrixed teams
Strong understanding of U.S. clinical research and healthcare environments
Compliance & Technical Requirements
Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
Commitment to compliant, ethical scientific exchange
Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)
Work Environment
Field-based role in the Northeast (Boston/New York), with residence required within assigned territory
~ 50% domestic travel expected, with significant time spent with external scientific partners
Why Join Tango Medical Affairs?
Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
Expand and establish Tango as a credible clinical scientific leader in precision oncology
Work in a lean, collaborative environment where your scientific judgment and execution matter
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
#LI-Remote
Salary range
$157,600—$236,400 USD
Apply To This Job