Senior Director, Clinical Pharmacology

Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.
Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.
Description of Role
Centessa is seeking an experienced Senior Director, Clinical Pharmacology to provide scientific and strategic leadership for clinical pharmacology across a diverse pipeline spanning early development through late-stage and registrational programs. Reporting to the Executive Director, Clinical Pharmacology, this position is accountable for developing and executing clinical pharmacology strategies that address the unique challenges of neuroscience drug development, including CNS exposure, dose optimization, and translational relevance. The Senior Director partners closely with cross-functional teams and represents clinical pharmacology in regulatory interactions to enable efficient, data-driven advancement of therapies across our neuroscience portfolio.
Key Responsibilities

Lead clinical pharmacology strategy for CNS and neuroscience programs from first‑in‑human through registrational and post‑marketing stages
Design, execute, and interpret clinical pharmacology studies, including FIH, multiple‑ascending dose, DDI, biopharmaceutics, and patient studies
Drive dose selection and optimization by integrating PK, PD, safety, efficacy, and CNS‑specific biomarkers
Lead model‑informed drug development, including population PK, PK/PD, and exposure–response analyses relevant to CNS targets and clinical safety
Assess and guide strategies for CNS exposure, brain penetration, target engagement, and translational biomarkers
Serve as the clinical pharmacology lead on program teams, clinical sub‑teams, and trial working groups
Author and oversee clinical pharmacology sections of regulatory documents (e.g., INDs, CTAs, IBs, NDAs)
Represent clinical pharmacology in interactions with FDA and other global health authorities, supporting dose justification and labeling discussions
Partner closely with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs
Oversee CROs and external vendors conducting clinical pharmacology and modeling activities
Ensure timely communication and clear interpretation of clinical pharmacology results to internal stakeholders
Contribute to portfolio strategy, program prioritization, risk mitigation, and long‑range clinical development planning for CNS assets
Serve as a subject‑matter expert on clinical pharmacology
Mentor and develop clinical pharmacology talent as the pipeline and organization grow
Ensure high‑quality, submission‑ready documentation aligned with global regulatory standards

Qualifications

PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline
8–12+ years of experience in clinical pharmacology within biopharma, with demonstrated impact in clinical drug development
Extensive experience developing and executing clinical pharmacology strategies for early‑ through late‑stage programs, including registrational support
Strong expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment
Demonstrated experience applying quantitative clinical pharmacology approaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization
Proficiency with clinical pharmacology tools and platforms such as NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent
Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities
Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development
Excellent communication, collaboration, and leadership skills with the ability to operate effectively in a fast‑paced, matrixed environment

Compensation
The annual base salary range for this position is $270,000.00 to $295,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.
In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success.
Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.
Work Location
The Senior Director, Clinical Pharmacology role is a remote role based in the US, with occasional travel.
POSITION: Full-Time, Exempt
EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.