Scientist I - Integrative Analysis of SEA-AD and Community Multiomics Datasets

Allen Institute is dedicated to advancing health through understanding the principles that govern life. The Scientist I role focuses on integrating, analyzing, and interpreting multiomics datasets related to Alzheimer's disease, collaborating with a team to develop computational tools and methodologies.ResponsibilitiesCollaborate with SEA-AD and SEA-AD IAC members and outside investigators to ensure community multiomic datasets are re-processed, their metadata is harmonized, and relevant secondary data types are obtained (e.g. whole genome sequencing, nuclear imaging, or blood based biomarkers)Adapt existing or develop novel computational tools to rigorously quantify changes in cell types in Alzheimer’s disease across community datasetsAssociate gene expression and chromatin accessibility changes with relevant and available donor metadata or secondary data typesCompare cell type changes across disease progression between studies regions to identify common early changes that may inform biomarkersInteract with scientists from diverse backgrounds and perspectives to design analytical approaches and refine computational strategiesWork with experimental scientists to design experiments to validate predictions of disease functionParticipate in a highly interactive and multidisciplinary environmentPublish and present findings in peer-reviewed journals and scientific conferencesSkillsPh.D. in Neuroscience, Computational Neuroscience, Computer Science, Applied Math, or related field; or equivalent combination of degree and experienceFluency programming in Python in high performance computingFluency with version control systems (e.g. Git/Github)Familiarity with analysis of RNA-sequencing or related data typesExperience with modeling disease or developmental trajectories, or related computational studiesAdditional experience in computational analysis and statistical assessment of biological datasets in other modalities such as spatial statistics, ATAC-seq analysis, computational anatomy, or related fieldsPrevious work on studying Alzheimer's disease or other neurodegenerative diseasesFamiliarity with additional programming languages (e.g., R)Experience with GPU-based deep learningAbility to work effectively in a highly collaborative environmentStrong written and verbal communication skillsAbility to work independently and collaborativelyStrong publication track recordBenefitsMedicalDentalVisionBasic life insurance401k planPaid time offCompany OverviewThe Allen Institute is dedicated to answering some of the biggest questions in bioscience and accelerating research worldwide. It was founded in 2003, and is headquartered in Seattle, Washington, USA, with a workforce of 501-1000 employees. Its website is https://alleninstitute.org/.Company H1B SponsorshipAllen Institute has a track record of offering H1B sponsorships, with 41 in 2025, 33 in 2024, 25 in 2023, 26 in 2022, 17 in 2021, 7 in 2020. Please note that this does not guarantee sponsorship for this specific role.



Apply Now