Scientist I, Clinical Pharmacology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a passionate and experienced Clinical Pharmacologist with strong background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a member of the Late Development Clinical Pharmacology group, you will: Provide strategic insight and technical leadership within the Clinical Pharmacology function. Author and provide technical input for regulatory documents and submissions related to all aspects of clinical pharmacology (including protocol, CSR, IB, briefing package, SCP/SBS, label etc). Participate in regulatory interactions and responses to regulatory questions. Apply state-of-the-art quantitative modeling, including translational PK/PD, population PK, and exposure-response analyses, to guide recommended phase 2 dose/schedule (RP2Ds) selection for pivotal studies. Work with the Clinical Development team in designing pivotal Phase 3 study. Engage and work with CROs on clinical pharmacology activities. Represent the Clinical Pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions. Manage internship and fellowship programs. Required Skills, Experience and Education: A Ph.D. or Pharm.D (with Fellowship) with Pharmaceutical Sciences or related disciplines is required with 0-2 years of relevant industry experience in Clinical Pharmacology. Prior experience with small molecules oncology drug development. Familiar with FDA’s Project Optimus guidance. Well-informed in current and emerging standards of regulatory requirements and expectations for clinical pharmacology. Expertise in clinical pharmacology, hands-on modeling, and simulation skills using NONMEM, R, and/or other modeling and simulation software. Experience with population PK, exposure-response, and advanced mechanistic PK/PD. Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences. A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment. Preferred Skills: Prior experience in NDA submission. #LI-Hybrid #LI-CT1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact [email protected] . Base Pay Salary Range $110,000 — $137,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to [email protected] so we can share these impersonations with our IT team for tracking and awareness.