[Remote] Sr. Director / Executive Director, Program Management (CMC)

Note: The job is a remote job and is open to candidates in USA. Tyra Biosciences is a biotechnology company focused on small molecule drug development. The Sr. Director / Executive Director, Program Management will lead cross-functional teams in Chemistry, Manufacturing, and Controls (CMC) to ensure successful development and commercialization of drug assets.ResponsibilitiesLead integrated, cross-functional small molecule drug development teams with strong emphasis on CMC strategy and execution, including drug substance, drug product, analytical development, formulation, process development, manufacturing, supply chain, and qualityAct as the primary program management partner to corporate program management and CMC leadership, ensuring technical development, manufacturing readiness, and regulatory strategies are fully aligned with overall asset strategy and corporate objectivesDevelop and maintain integrated development plans covering, regulatory, and CMC activities across discovery, IND-enabling, early clinical, late-stage development, and commercializationDrive CMC execution for small molecules including candidate selection support, IND-enabling activities, tech transfer to internal and external manufacturing, clinical supply strategy, scale-up, validation, and lifecycle managementPartner closely with Regulatory Affairs to align small molecule CMC strategies for global IND, CTA, NDA filings, and health authority interactionsLead proactive identification and mitigation of program risks with particular focus on CMC, manufacturing robustness, supply continuity, and GMP compliancePrepare clear, data-driven program updates, dashboards, and decision materials for governance committees and executive leadershipCoordinate and oversee external partners including CDMOs, testing labs, and development vendors to ensure timely delivery of CMC and development milestonesEnsure consistent program execution disciplines, meeting excellence, documentation, and communication across all development functionsContribute to continuous improvement of program management best practices, SOPs, tools, and governance models tailored to small molecule developmentSkillsAdvanced scientific degree (BS/MS/PhD) in chemistry, chemical engineering, pharmaceutical sciences, or related field; MBA and/or PMP certification preferred10–15+ years of experience in pharmaceutical or biotechnology companies leading drug development or program management activitiesDemonstrated expertise in small molecule drug development with strong hands-on involvement in CMC-driven programs across multiple clinical phasesDeep understanding of small molecule CMC, including synthetic chemistry, solid-state and formulation development, analytical development, manufacturing scale-up, tech transfer, GMP operations, and CMC regulatory requirementsProven ability to lead complex, global, cross-functional teams in matrixed environments and drive execution without direct authorityExperience managing external partnerships and CDMOs supporting drug substance and drug product development and commercial supplyStrong leadership, communication, and executive presence, with the ability to synthesize complex technical information for senior decision-makingTrack record of operating effectively in fast-paced, ambiguous environments with multiple concurrent programsCandidates must be authorized to work in the U.STravel may be required up to 10%Extensive background leading global, cross-functional development teams spanning clinical, regulatory, and CMC for small molecule programs from discovery or preclinical through NDA approval and commercializationPrior experience directly leading or partnering with CMC organizations responsible for drug substance and drug product development, manufacturing, and technical transferExperience overseeing Phase 1–3 development programs, including late-stage registration and NDA/MAA submissionsHands-on experience working with global CDMOs and manufacturing partners, including oversight of GMP operations and supply chain readinessEarly-career or direct experience in pharmaceutical development, chemistry, formulation, or manufacturing providing strong technical foundation for CMC leadershipDemonstrated success driving integrated program strategy, governance, and risk management across complex portfoliosExperience working closely with executive leadership teams and contributing to enterprise-level development and portfolio decisionsExcellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelinesProven ability to manage competing priorities in a fast-paced, rapid-growth environmentAbility to work independently and collaboratively adapt as part of a teamStrong interpersonal skills, including verbal and written communicationBenefitsCompetitive base, bonus, new hire and ongoing equity packagesThe starting compensation range(s) for this role is for a full-time employee (FTE) basisBenefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollmentEmployer-paid Medical, dental, and vision insuranceEmployer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage401(k) Plan with a fully vested company match 1:1 up to 4% of contributionsEmployee Stock Purchase Plan14 -18 paid holidays, including office closure between December 25th and January 1stFlexible vacationSick timeFitness ProgramGet Outdoors ProgramPaid parental leave benefitTuition assistanceCompany OverviewTyra Biosciences is a biotechnology company targeting new pathways of acquired resistance in oncology with purpose-built drugs. It was founded in 2018, and is headquartered in Carlsbad, California, USA, with a workforce of 11-50 employees. Its website is https://tyra.bio/.