[Remote] Senior Machine Learning Engineer

Note: The job is a remote job and is open to candidates in USA. Amgen is a leading biotechnology company dedicated to serving patients with serious illnesses. They are seeking a Senior Machine Learning Engineer to build high-impact AI proofs-of-concept, collaborating with product managers and business stakeholders to develop scalable AI solutions that deliver measurable value.ResponsibilitiesBuild scalable AI proof-of-concepts that are designed to demonstrate a clear path from prototype to enterprise-scale solutionPartner with product managers, business stakeholders, platform teams, and AI & software engineers to translate ambiguous business needs into practical AI solutions with measurable valueDesign and implement modern AI systems using LLMs, agentic workflows, retrieval-augmented generation, data pipelines, APIs, cloud-native services, and enterprise platformsRapidly validate feasibility and value by assessing technical risk, data readiness, integration complexity, user experience, security considerations, performance, cost, and business impactCreate reusable technical assets such as reference architectures, reusable components, documentation, decision records, and handoff materials that enable product, platform, or delivery teams to scale successful POCsRaise the technical bar for the team by modeling strong engineering practices, mentoring others, improving delivery patterns, and bringing clear ownership and accountability to uncertain, fast-moving workSkillsDoctorate degreeORMaster's degree and 2 years of relevant experienceORBachelor's degree and 4 years of relevant experienceORAssociate's degree and 8 years of relevant experienceORHigh school diploma / GED and 10 years of relevant experience4-6 years of relevant experience in AI engineering, machine learning engineering, software engineering, data engineering, cloud engineering, or related technical rolesDemonstrated experience building full-stack AI-powered applications that move beyond experimentation and are designed with scalability, security, evaluation, and maintainability in mindStrong understanding of modern AI application architecture, including LLMs, retrieval-augmented generation, embeddings, vector databases, agentic workflows, tool use, orchestration frameworks, and AI evaluation methodsExperience defining and applying evaluation methods for AI solutions, including accuracy, reliability, hallucination risk, latency, usability, safety, cost, and fitness for intended useAbility to translate ambiguous business problems into practical technical approaches, make sound tradeoffs, and rapidly validate feasibility, value, risks, and path to scaleExperience with AWS Cloud, data pipelines, integration architecture, containers, CI/CD, observability, and secure development practicesStrong software engineering foundation, preferably with Python and modern development practices, including testing, version control, modular design, documentation, and maintainable codeDemonstrated ability to responsibly use AI tools to improve engineering productivity, explore technical solutions, automate repetitive tasks, and enhance the delivery of machine learning or software productsExcellent communication, ownership, and cross-functional leadership skills, with the ability to partner effectively with product managers, business stakeholders, platform teams, and AI and software engineersBenefitsA comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this appliesCompany OverviewAmgen is a biotechnology company that develops and manufactures human therapeutics for various illnesses and diseases. It was founded in 1980, and is headquartered in Thousand Oaks, California, USA, with a workforce of 10001+ employees. Its website is http://www.amgen.com.Company H1B SponsorshipAmgen has a track record of offering H1B sponsorships, with 42 in 2026, 429 in 2025, 485 in 2024, 485 in 2023, 540 in 2022, 460 in 2021, 444 in 2020. Please note that this does not guarantee sponsorship for this specific role.