[Remote] Clinical Director, Oncology Clinical Development

Note: The job is a remote job and is open to candidates in USA. Natera is seeking an experienced Clinical Director, Oncology Clinical Development to provide medical and scientific leadership for Natera-sponsored oncology clinical trials focused on minimal residual disease (MRD). In this pivotal role, you’ll drive the design and execution of biomarker-driven interventional and randomized studies that integrate MRD testing into precision oncology strategies.ResponsibilitiesServe as the program-level medical lead for Natera-sponsored MRD clinical trials across assigned oncology indications, with ultimate accountability for clinical outcomes, data integrity, and patient safetyDefine clinical development strategies that align study design, endpoints, and execution with regulatory and scientific objectivesProvide medical oversight across the full trial lifecycle, from design and protocol development through first patient in (FPI), data readout, and study close-outProvide strategic and medical guidance to Clinical Scientists, fostering collaboration on protocol design, data interpretation, and translational insights that drive clinical program successAct as Medical Monitor, overseeing safety signal detection, adverse event review, and risk mitigation in compliance with GCP and regulatory requirementsPartner cross-functionally with Clinical Science, Clinical Operations, Data Management and Biostatistics to ensure timely and successful study execution, operational feasibility, and data qualityCollaborate with Regulatory Affairs to support submissions, regulatory interactions, and responses, as appropriateRepresent Natera as the clinical development lead in interactions with investigators, key opinion leaders, IRBs, and regulatory authoritiesGuide interpretation of interim and final analyses, ensuring scientific accuracy and clinical relevanceProvide strategic leadership for clinical study reports, and other required study-related clinical and regulatory documentation in collaboration with cross-functional partnersLead authorship and strategy for manuscripts, abstracts, and conference presentations in collaboration with Clinical Science, Biostatistics, Translational Medicine and Scientific CommunicationsShape and influence the evolution of Natera’s Clinical Development organization by establishing governance standards, decision frameworks, and best practices that ensure high-quality, audit-ready execution across sponsored studiesProvide senior-level mentorship and clinical leadership to Clinical Scientists, enabling consistent application of scientific rigor and regulatory standards across clinical programsSkillsMD (or equivalent)≥3 years of industry experience in oncology clinical developmentDemonstrated experience serving as Medical Monitor or clinical lead for Phase II–III studiesStrong working knowledge of GCP, ICH guidelines, and regulatory expectations for interventional trialsProven ability to interpret and communicate complex clinical data to internal and external stakeholdersBoard certification in Medical Oncology or Hematology/OncologyExperience with biomarker-driven development, molecular diagnostics, or MRD-focused programsPrior involvement in regulatory interactions (e.g., FDA meetings, briefing documents)Experience working within matrixed clinical development organizationsBenefitsComprehensive medical, dental, vision, life and disability plans for eligible employees and their dependentsNatera employees and their immediate families receive free testingFertility care benefitsPregnancy and baby bonding leave401k benefitsCommuter benefitsGenerous employee referral programCompany OverviewNatera specializes in cell-free DNA testing to provide a more targeted interventions to oncology, women's health, and organ health. It was founded in 2004, and is headquartered in San Carlos, California, USA, with a workforce of 5001-10000 employees. Its website is https://www.natera.com/.Company H1B SponsorshipNatera has a track record of offering H1B sponsorships, with 6 in 2026, 90 in 2025, 72 in 2024, 37 in 2023, 71 in 2022, 64 in 2021, 40 in 2020. Please note that this does not guarantee sponsorship for this specific role.